Table 2.

Comparison of mcfDNA vs Blood Culture for the Detection of the Microbiologic Agent of Definite Infective Endocarditis^a

		mcfDNA
		True Positive	False Negative	False Positive
Blood culture	True Positive	19	1	0
	False Negative	1	0	1
	False Positive	0	1	0

Blood culture sensitivity: 20/23 = 87%. mcfDNA sensitivity: 20/23 = 87%.

Abbreviation: mcfDNA, microbial cell-free DNA.

True microbiologic agent of infective endocarditis for each case was determined by an adjudication panel of 3 independent board-certified physicians using clinical, microbiological, and histopathologic data.

Mean time from antibiotic start to index test draw was −0.09 days (±0.5 days) for blood culture and 11.1 days (±11.7 days) for mcfDNA.