FIG. 3.

Maximum lesion size of mice immunized with peptide-DT conjugates. BALB/c mice were immunized s.c. with the peptide-DT conjugates (50 μg) administered in IFA for the primary and secondary doses and challenged s.c. 12 days after the second dose with P. gingivalis ATCC 33277 (7.5 × 10⁹ viable cells). Animals were monitored over a 14-day period for weight loss and lesion size. Data were analyzed using the Mann-Whitney U-Wilcoxon rank sum test. ∗, Groups significantly different (P < 0.005) to the DT control group. FK, formalin killed.