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. 2023 Apr 26;14:1183491. doi: 10.3389/fphar.2023.1183491

FIGURE 1.

FIGURE 1

Genetic association of SCARs between HLA and drugs. The drugs (antibiotics or AODs) trigger DHRs through MHC/drug/TCR complex. SJS/TEN mainly 694 started immune mechanism by HLA/drug/CTLs and HLA/drug/Th cells, while DRESS mainly 695 started immune mechanism by HLA/drug/CTLs and HLA/drug/Th2 cells. Co-trimozaxole can induce 696 SJS/TEN and DRESS through binding to HLA-A*11:01/HLA-B*38 and HLA-B*13:01, 697 respectively. Dapsone can induce SJS/TEN and DRESS through binding to HLA-B*1301. 698 Vancomycin can induce DRESS by binding to HLA-A*32:01 and HLA-B*67:01. SR can activate 699 SJS/TEN through binding to HLA-A*33:03. Abbreviations: AOD, anti-osteoporotic drug; APC, antigen-presenting cell; CTL, cytotoxic T 701 lymphocyte; DHR, delayed hypersensitivity reaction; DRESS, drug reaction with eosinophilia and 702 systemic symptoms; HLA, human leukocyte antigen; MHC, major histocompatibility complex; SJS, 703 Stevens-Johnson syndrome; TCR, T cell receptor; TEN, toxic epidermal necrolysis; Th cell, T helper 704 cell.