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. 2023 Mar 16;37(5):1068–1079. doi: 10.1038/s41375-023-01867-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A OPN plasma concentration was evaluated by means of ELISA (enzyme-linked immunosorbent assay) in control mice (Untreated) and Romiplostim-treated animals receiving vehicle (Rom + Vehicle, in blue), Ulixertinib (Rom + Ulix, in green), Ruxolitinib (Rom + Ruxo, in red) or a combination of Ulixertinib and Ruxolitinib (Rom + Ruxo + Ulix, in purple). ELISA was performed 11 days after the first Romiplostim administration (n = 7–9/group). Histograms represent mean values while bars indicate the standard deviation. Comparisons were performed by means of one-way ANOVA. B Blinded fibrosis grade quantification was performed by a specialized pathologist (n = 4–8/group) Histograms represent median values while bars indicate the interquartile range. Comparisons were performed by means of Kruskal-Wallis’ test. C Representative images of Gordon and Sweet’s reticulin staining of BM sections from mice belonging to each experimental group. Magnification 200×. D Spleen fibrosis as shown by Gordon and Sweet’s reticulin staining. Magnification 200X. *: P ≤ 0.05; **: P ≤ 0.01; ***: P ≤ 0.001; ****: P ≤ 0.0001 Abbreviations: OPN osteopontin; Rom romiplostim; Ulix Ulixertinib; Ruxo Ruxolitinib; BM bone marrow.