Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 26;14:1168589. doi: 10.3389/fimmu.2023.1168589

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Lagisquet, Conrad, Wittmann, Volkmann, Weissinger, Sticht and Gramberg

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The amino acid exchange H43Y stabilizes the TRIM5α structure. (A) Overlay of TRIM5α WT (green) and the H43Y variant (orange) illustrates the differences in side chain length. (B) TRIM5α H43: the H43-Y62 distance allows for only weak hydrogen bond formation (represented by dashed line). (C) TRIM5α H43Y: the distance Y43-Y62 is shorter resulting in a stronger hydrogen bond (represented by a bold black line). (D) TRIM5α H43: the WT histidine shows no van der Waals contacts to P64. (E) TRIM5α H43Y: Y43 forms van der Waals contacts to P64 that stabilize the structure.