Table 2.
Selected economic evaluations of catheter ablation for atrial fibrillation.
| Study (Year) | Patient population | Analysis/Methodology | Country | Intervention vs. Comparator | Time Horizon | Currency | Incremental Cost Effectiveness Ratio | Reference |
|---|---|---|---|---|---|---|---|---|
| McKenna (2009) | Patients with paroxysmal AF refractory to medical therapy | CUA/Markov model | United Kingdom | Catheter ablation vs. AAD | Lifetime | 2006 GBP | £7763–£7910/QALY | (34) |
| Blackhouse (2013) | Patients with drug-refractory AF | CUA/Markov model | United States | Catheter ablation vs. amiodarone | 5 years | 2010 CDN | $59,194/QALY | (35) |
| Aronsson (2015) | Patients with symptomatic, antiarrhythmic drug naïve AF within the preceding 6 months. | CUA/Markov model | Sweden | Catheter ablation vs. AAD | Lifetime | 2012 Euros | €50,570/QALY | (36) |
| Chew (2022) | Patients with paroxysmal or persistent AF aged ≥65 years or <65 years with ≥1 risk factors for stroke | CUA/Trial-based | United States | Catheter ablation vs. medical therapy | Lifetime | 2018 USD | $57,893/QALY $183,318/LY |
(28) |
| Catheter ablation in Atrial Fibrillation and Heart Failure | ||||||||
| Gao (2019) | Patients with concomitant symptomatic AF and HF with reduced EF | CEA and CUA/ Markov model | Australia | Catheter ablation vs. medical therapy | Lifetime | AUD | $55,942/QALY $35,020/LY |
(37) |
| Chew (2020) | Patients with concomitant symptomatic AF and HF with reduced EF | CUA/Markov model | United States | Catheter ablation vs. medical therapy | Lifetime | 2018 USD | $38,496/QALY | (38) |
| Lau (2021) | Patients with concomitant symptomatic AF and HF with reduced EF | CUA/Markov model | Canada | Catheter ablation vs. medical therapy | Lifetime | 2018 CDN | $35,360/QALY | (30) |
AAD, antiarrhythmic drug; AF, atrial fibrillation; AUD, Australian Dollar; CDN, Canadian Dollar; CUA, cost utility analysis; GBP, British Pound Sterling; EF, ejection fraction; HF, heart failure; QALY, quality adjusted life years; LY, life years; USD, US Dollar.