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IL-10−/− mice succumbed to infection with a regular sublethal dose of T. cruzi. Groups of five mice were infected i.p. with 50 blood trypomastigotes of the Tulahuen strain, and parasitemia was recorded twice a week. Shown are the kinetics of parasitemia (A) and survival (B). The means and standard deviations of one representative of three independent experiments are shown. ∗, significantly different from values of heterozygous littermates (P < 0.05; Mann-Whitney and U Wilcoxon test).
