FIG. 6.

Neutralization of TNF-α increases survival time and delays body weight loss and hypothermia in T. cruzi-infected IL-10^−/− mice. Groups of two to seven mice were infected i.p. with 50 trypomastigotes of the Tulahuen strain of T. cruzi. One day prior to infection and twice a week after infection, the IL-10^−/− mice were treated with either antiserum (▴) or control serum (○). Infected IL-10 heterozygous littermates (●) were included as a positive control for survival. Shown are the survival time (A), the kinetics of the body weight change (B), and the rectal body temperature (C). The results in panels B and C are presented as the mean of individually scored mice (twice a week), including the standard deviation. One representative of two independent experiments is shown.