Fig. 7. Anti-tumor activity of SNAP-CAR T cells in vivo in a human tumor xenograft mouse model.

a In vivo experimental design. b IVIS imaging of tumor burden over time. c Quantification of tumor growth via luciferase intensity for mouse images in b. “PR” indicates partial response which is defined by a final tumor size over baseline but <10⁹ at day 33 (relative light units, RLU). d Survival of treated mice over time. For d a Mantel-Cox log-rank test was performed with a Bonferroni correction for multiple comparisons and “ * ” denotes a significance of p < 0.01667 for three comparisons, n = 5 mice. Exact p-values are p = 0.0135 for adaptor only and p = 0.0031 for SNAP-CAR T cells only. Source data are available as a Source Data file.