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. 2023 May 9;14:2672. doi: 10.1038/s41467-023-37864-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Chemical structures of a synthetic cannabinoid (MDMB-Fubinaca, FUB), a phytocannabinoid ((−)-trans-Δ⁹-tetrahydrocannabinol, (-)Δ⁹-THC) and the endocannabinoids (anandamide and 2-Arachidonoylglycerol, 2-AG). Structures of analogs of phytocannabinoid (CP 55940, CP) and endocannabinoid (AMG315 and AM8125) were used in this study. b GTP turnover assay showing efficient turnover produced by CP (CP 55940), AMG315 and anandamide with G_i1 (Data normalization done with FUB (MDMB-Fubinaca) as 100% and receptor alone as 0%). Data represented as mean ± SD, p < 0.0001****, p = 0.0026** and p = 0.0507 (ns), unpaired t-test (two-tailed), n = 3 independent). c Bimane spectra monitoring TM6 showing differences between anandamide-bound CB1 compared to CP (CP 55940) and AMG315 (Data represented as mean ± SD, n = 3 independent experiment).