Table 2.
Mean (± SD) inhibition diameters at 72 h and range to fluconazole (FLZ), itraconazole (ITZ), ketoconazole (KTZ) and amphotericin B (AMB) by both disk diffusion tests performed in strains from healthy animals, animals with otitis and animals with dermatitis
| HEALTHY (n = 9) | OTITIS (n = 67) | DERMATITIS (n = 13) | TOTAL (n = 89) | p value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | X ± SD | range | n | X ± SD | range | n | X ± SD | range | n | X ± SD | range | ||
| FLZ | |||||||||||||
| R 25 µg | 4 | 32.25 ± 2.90 | 29.00–36.00 | 67 | 30.50 ± 10.31 | 7.50–56.50 | 12 | 30.38 ± 11.76 | 0- 42.00 | 83 | 30.57 ± 10.22 | 0–56.50 | 0.945 |
| B 25 µg | 8 | 35.19 ± 3.94 | 28.00–39.00 | 66 | 33.68 ± 12.82 | 5–73.00 | 12 | 35.75 ± 17.06 | 0- 68.00 | 86 | 34.11 ± 12.49 | 0–73.00 | 0.775 |
| ITZ | |||||||||||||
| R 10 µg | 8 | 36.44 ± 3.97 | 29.50–42.00 | 67 | 39.43 ± 6.80 | 19.0–58.00 | 12 | 39.88 ± 5.41 | 28.00–47.50 | 87 | 39.22 ± 6.43 | 19.00– 58.00 | 0.433 |
| KTZ | |||||||||||||
| R 15 µg | 8 | 48.94 ± 2.80 | 44.00–53.00 | 67 | 53.78 ± 7.88 | 20.00–73.00 | 12 | 53.71 ± 3.86 | 45.50–59.00 | 87 | 53.32 ± 7.22 | 20.00–73.00 | 0.199 |
| B 50 µg | 8 | 56.94 ± 3.45 | 53.00–63.00 | 67 | 62.79 ± 6.45 | 38.50–78.00 | 13 | 66.85 ± 5.12 | 57.50–77.00 | 88 | 62.86 ± 6.46 | 38.50–78.00 | 0.002 |
| AMB | |||||||||||||
| R 10 µg | 4 | 16.63 ± 0.75 | 15.50–17.00 | 67 | 17.33 ± 2.99 | 0–22.00 | 12 | 17.88 ± 1.55 | 15.00–20.00 | 83 | 17.37 ± 2.76 | 0–22.00 | 0.706 |
| B 100 µg | 8 | 19.88 ± 1.22 | 18.00–22.00 | 67 | 19.88 ± 2.73 | 13.00–27.50 | 13 | 19.46 ± 2.20 | 16.00–23.00 | 88 | 19.82 ± 2.54 | 13.00–27.50 | 0.530 |
R, Rosco©; B, Bio-Rad©