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. 2023 Mar 4;50(3):147–172. doi: 10.1007/s10928-023-09850-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A diagram illustrating the multistate model describing the different states and transitions in the patient population studied. λij represents the transition intensities between states, n for the transitions represents the number of observed transitions, n for the states is the number of clinical outcomes at the end of the study. dSLD change in SLD between previous 2 measures, relSLD relative change from baseline, SLD sum of the largest diameter (tumor data); TTP time to progression.

Adapted from Krishnan et al. [13]