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. 2023 Jan 1;39(5):745–758. doi: 10.1007/s12264-022-01011-8

Fig. 2.

Fig. 2

Ntn-3 deficiency triggers hypersensitivity of mechanical and cold allodynia in diabetic mice. A Ntn-3 KO mice perform normally in the glucose tolerance test. n = 8 mice per group. B, C Weekly blood glucose tests and body weight measurements indicate that Ntn-3 KO mice respond to STZ-induced hyperglycemia in a similar manner to that of WT littermates. *P < 0.05; **P < 0.01; ns, no significant difference by two-way ANOVA. n = 8–12 mice per group. D The mechanical pain threshold is significantly decreased in Ntn-3 KO mice compared with WT littermates during DNP progression. *P < 0.05; **P < 0.01 compared with the WT+STZ group by two-way ANOVA. n = 11 mice per group. E Increased cold allodynia in Ntn-3 KO mice compared with WT littermates at week 4 after STZ administration. **P < 0.01 by two-way ANOVA. n = 8–10 mice per group. F No significant differences are found in thermal hyperalgesia between diabetic Ntn-3 KO and WT mice. n = 7 mice per group. **P < 0.01. ns, no significant difference by two-way ANOVA.