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. 2023 Jan 1;39(5):745–758. doi: 10.1007/s12264-022-01011-8

Fig. 4.

Fig. 4

Ntn-3 deficiency causes the intra-epidermal sprouting of DRG sensory axons in diabetic mice. A Representative images of GAP-43 staining in hind paw skin samples were collected four weeks after STZ administration. Scale bar, 50 µm. B Quantification of GAP-43 staining showing significantly increased axon sprouting in diabetic Ntn-3 KO mice compared with diabetic WT mice. **P < 0.01 by two-way ANOVA. n = 6–8 mice per group. C Representative images of CGRP and Dil double-labeled primary sensory neurons in the DRGs of diabetic Ntn-3 KO mice. Scale bar, 100 μm. Boxed regions of the merged images are enlarged on the right. Scale bar, 15 μm. D Percentages of NF200+, IB4+, CGRP+ neurons relative to Dil+ neurons in diabetic WT and Ntn-3 KO mice. Ntn-3 KO selectively facilitates the epidermal innervation of CGRP+ DRG neurons. *P < 0.05; ns, no significant difference by two-way ANOVA. n = 6 mice per group.