Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 9;14(5):317. doi: 10.1038/s41419-023-05818-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Crown 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — A (I) Normalised mRNA log₂ count of each gene modulated either by knockout of TGM2 or add-back of either isoform of TGM2 using NanoString Cancer progression panel, data plotted using Morpheus from Broad Institute https://software.broadinstitute.org/morpheus/. Hierarchical clustering and One minus Pearson Correlation in rows and columns. Intense blue to less intense blue signifies range of gene under expressed, while light red to intense red signifies range of gene over expressed as indicated in the key. Red asterisks indicate genes restored after add-back of TGM2_v1 and/or TGM2_v2. (II) log₂ Fold change representation of genes upregulated and downregulated in PC3 TG2KO clones compared to WT PC3 clones. (III) Pie chart categorising the differentially expressed genes into cancer progression categories according to NanoString Cancer progression panel. Each cancer progression category shown with the percentage of gene hit against total number of cancer progression categories. B, C Five genes significantly restored up to WT levels upon add-back of TGM2_v2 and/or TGM2_v1. Scatter plots of normalised mRNA linear count for each differentially expressed gene (mean ± SD). Each symbol represents a clone. Blue triangles represent each WT clone, the red squares represent each TG2KO clone, green circle represents TGM2_v1 add-back clone, yellow circle represents TGM2_v2 add-back clone. Benjamini–Hochberg (BH) multiple correction test: *p ≤ 0.05.