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. 2023 May 9;10:261. doi: 10.1038/s41597-023-02158-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Correlating CSF peptide biomarker abundances to amyloid, Tau, and cognitive measures. (a) Positive (red) and negative (blue) Pearson correlations between biomarker peptide abundance and immunoassay measures of Aβ(1–42), total Tau, phospho-T181 Tau (pTau), ratio of total Tau/Aβ, and cognition (MoCA score). Student’s t test significance is indicated by overlain asterisks; *p < 0.05, **p < 0.01, ***p < 0.001. (b) Individual correlation scatterplots are shown for SMOC1 (upper row), YWHAZ (middle row), and VGF (lower row). Individual cases are colored by their diagnosis; blue for controls, red for AsymAD cases, and green for AD cases. Amyloid immunoassay measures of 1,700 (maximum, saturated value in the assay) were not considered for correlation. Pearson correlations (rho), Student p values of correlation significance, and numbers of paired observations for correlation of biomarker peptide abundances to immunoassay measures of Aβ(1–42), total Tau, phospho-T181 Tau, and the ratio of total Tau/ Aβ are in the ELISA_PearsonCors file in the Data folder on Synapse²⁵.