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. 2023 May 9;10:261. doi: 10.1038/s41597-023-02158-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Receiver-operating characteristic (ROC) curve analysis of peptide diagnostic potential. ROC curves for each of three pairs of diagnosed case groups were generated to determine the top-ranked diagnostic biomarker peptides among the 58-peptide panel plus 4 APOE specific peptides. (a) A total of 263 AD (N = 130) and control (N = 133) CSF case samples were classified according to the logistic fit for each peptide’s log2(ratio) measurements across these samples, and the top 5 ranked by AUC are shown. (b) Top five performing peptides for discerning AsymAD (N = 127) from control (N = 133) case diagnosis groups are provided with AUCs, nominating these peptides as potential markers of pre-symptomatic disease, and as cognates for AT+ biomarker positivity. (d) Symptomatic AD (N = 130) and AsymAD (N = 127) discerning peptides were ranked by AUC and the top five ROC curves are shown and nominated as cognate CSF measures for compromised patient cognition. ROC curve statistics including AUC, p, 95% DeLong confidence interval, accuracy, specificity, and sensitivity for dichotomous diagnosis case sample groups are in the ROCstatistics file in the Data folder on Synapse²⁵.