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. 2023 May 9;13:159. doi: 10.1038/s41398-023-02451-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Within-group correlations between change in QIDS-SR (A, C, E) or MADRS (B, D, F) scores and the change in mean diffusivity for select brain regions. Post hoc Pearson r and p values shown separately for the vehicle (n = 31) and ketamine (n = 67) groups; see main text and Table 2 for full omnibus regression statistics. A positive change in depression score indicates an improvement in depression on that scale, and a positive change in MD indicates decreased diffusion in that region (interpreted as increased plasticity).