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. 2023 Mar 29;52(4):20220333. doi: 10.1259/dmfr.20220333

Table 3.

Studies on the use of MRI for the display of the periapical region. Technical information is given in Supplementary Table 3.

Authors Study design/subjects Research question Findings
Geibel et al. 2015 37 19 participants (43 +- 13 y), 34 teeth Applicability of MRI for the assessment of periapical lesions and individual comparison of MRI and CBCT findings
  • Overestimation of dimension of lesions with MRI compared to CBCT;

  • More detailed characterisation of lesions with MRI;

  • T 2 weighted sequences showed heterogeneity of periapical pathologies

Geibel et al. 2017 38 13 participants (41 +- 27 y), 15 teeth Assessment of periapical lesions and characterisation of lesions with MRI using different contrast weightings; correlation with histopathology
  • T 1 weighted images for identification of lesions;

  • T 2 weighted images for further characterisation of lesions;

  • Differential diagnosis of periapical lesions possible by assessing homogeneity/heterogeneity of signal, signal inside the lesion compared to surrounding tissue;

  • Differences in signal intensity between T 1- and T 2 weighted images

Juerchott et al. 2018 39 11 participants (mean 39.5 y, range 21–60 y), 11 teeth Assessment and characterisation of periapical lesions with MRI using different contrast weightings and contrast agent, correlation with histopathology
  • All lesions were detected with MRI,

  • High reproducibility of lesion measurements in MRI;

  • No predictable differentiation of lesions with non-contrast-enhanced T 1 weighted images,

  • Differentiation of peripheral rim, lesion centre and surrounding tissue with contrast-enhanced T 1- and T 2 weighted sequence;

  • MRI characteristics in accordance with result of histopathological analysis

Lizio et al. 2018 36 34 patients Diagnostic reliability and accuracy of MRI for periapical lesions, correlation with histopathology
  • Endosseous lesions clearly visible in T1, T2 and contrast-enhanced T1 images,

  • Two diagnostic patterns established related to signal intensity, signal heterogeneity, margins, low-intensity outline and contrast agent distribution;

  • High interrater reliability for histopathological diagnosis of periapical lesions;

  • Specificity: 0.50 and 0.63, respectively, and sensitivity: 0.94

Pigg et al. 2014 40 20 patients (mean 52, range 34–65 y) Assessment of signal changes in MRI in patients with atypical odontalgia and correlation of MRI and CBCT
  • MRI and radiographic imaging coincided with a finding in 75% of patients with atypical odontalgia and chronic pain;

  • 3D CISS redundant for periapical diagnosis without radiological correlate displayed findings in MRI,

  • 40% of patients with odontalgia had changes in region in MRI

Cassetta et al. 2012 35 10 patients (mean age: 38.8 y, range 21–63 y) Assessment of MRI for intraosseous pathological findings, characterisation of MRI findings and correlation to histopathology
  • Odontogenic cysts appeared with homogenous high and intermediate signal intensity in water and fat T 2 weighted images, respectively,

  • Contrast agent administration resulted in thin rim enhancement in T 1 weighted images

CBCT, cone beam CT; 3D CISS, three-dimensional constructive interference in steady state.