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. 2023 Apr 20;49(6):114. doi: 10.3892/or.2023.8551

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Knockdown of TFAP2A inhibits the proliferation, migration and invasion, and promotes the apoptosis of cervical cancer cells. (A) Wound healing assay revealed that the downregulation of TFAP2A significantly reduced the cell migration rate. Representative images were obtained at 48 h. Scale bars, 100 µm. (B) Cell Counting Kit-8 assays revealed that the downregulation of TFAP2A reduced the growth rate. (C) Colony formation assay revealed that the downregulation of TFAP2A reduced the growth rate. (D) Apoptosis detection using flow cytometric analysis revealed that downregulation of TFAP2A promoted the apoptotic rate. (E) Transwell assay revealed that the downregulation of TFAP2A reduced the migration and invasion rate. n=3 in each group. *P<0.05, **P<0.01 and ***P<0.001. TFAP2A, transcription factor AP-2 alpha; sh-, short hairpin.