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. 2023 Apr 20;49(6):114. doi: 10.3892/or.2023.8551

Figure 4.

Figure 4.

TFAP2A and PD-L1 form a positive feedback pathway, which may be regulated by HPV E6 protein. (A) Western blot analysis revealed that TFAP2A expression was reduced in PD-L1-overexpressing cervical cancer cell lines. (B) Western blot analysis revealed that TFAP2A expression was reduced in cervical cancer cell lines in which PD-L1 was knocked down. (C) Western blot analysis revealed that TFAP2A and PD-L1 expression was reduced in cervical cancer cells in which HPV E6 was knocked down. n=3 in each group. *P<0.05, **P<0.01 and ***P<0.001. TFAP2A, transcription factor AP-2 alpha; PD-L1, programmed death-ligand 1; sh-, short hairpin.