Table 2.
Predictive power of molecular and pathological factors for pCR.
| Variable | Pathological response |
P | Odds ratio (95% CI) | PPV (%) | NPV (%) | Sensitivity (%) | Specificity (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| pCR (n = 57) |
RD (n = 263) |
|||||||||
| n | % | n | % | |||||||
| TP53 signature | ||||||||||
| Wild-type signature (n = 171) | 5 | 2.9 | 166 | 97.1 | <.0001 | 1 | 34.9 | 97.1 | 91.2 | 63.1 |
| Mutant signature (n = 149) | 52 | 34.9 | 97 | 65.1 | 17.8 (6.8-46.1) | |||||
| Grade | ||||||||||
| 1-2 (n = 150) | 8 | 5.3 | 142 | 94.7 | <.0001 | 1 | 30.5 | 94.7 | 85.5 | 57.0 |
| 3 (n = 154) | 47 | 30.5 | 107 | 69.5 | 7.8 (3.5-17.2) | |||||
| Intrinsic subtype | ||||||||||
| Luminal A (n = 114) | 3 | 2.6 | 111 | 97.4 | <.0001 | 1 | 26.2 | 97.4 | 94.7 | 42.2 |
| The others (n = 206) | 54 | 26.2 | 152 | 73.8 | 13.1 (4.0-43.1) | |||||
| ER | ||||||||||
| Positive (n = 198) | 19 | 9.6 | 179 | 90.4 | <.0001 | 1 | 31.9 | 90.4 | 66.7 | 68.8 |
| Negative (n = 119) | 38 | 31.9 | 81 | 68.1 | 4.4 (2.4-8.1) | |||||
| PR | ||||||||||
| Positive (n = 176) | 19 | 10.8 | 157 | 89.2 | .0002 | 1 | 27.1 | 89.2 | 66.7 | 60.6 |
| Negative (n = 140) | 38 | 27.1 | 102 | 72.9 | 3.1 (1.7-5.6) | |||||
Abbreviations: CI, confidence interval; ER, estrogen receptor; NPV, negative predictive value; pCR, pathological complete response; PPV, positive predictive value; RD, residual disease.