Table 3.
Univariate and multivariate analyses (Cox proportional hazard model) for DRFS in patients with RD.
| Variable | Patients with RD |
||||||
|---|---|---|---|---|---|---|---|
| n | Univariate |
Multivariate |
|||||
| HR | 95% CI | P | HR | 95% CI | P | ||
| Age | |||||||
| >50 | 120 | 1.00 | – | — | |||
| ⩽50 | 143 | 1.14 | 0.65-2.00 | .64 | |||
| T category | |||||||
| 1-2 | 193 | 1.00 | – | – | |||
| 3 | 70 | 1.48 | 0.82-2.65 | .19 | |||
| Nodal status | |||||||
| Negative | 121 | 1.00 | – | – | 1.00 | – | – |
| Positive | 142 | 1.90 | 1.06-3.42 | .032 | 2.13 | 1.12-4.03 | .020 |
| ER | |||||||
| Positive | 179 | 1.00 | – | – | 1.00 | – | – |
| Negative | 81 | 3.34 | 1.91-5.83 | <.0001 | 1.57 | 0.71-3.45 | .26 |
| PgR | |||||||
| Positive | 157 | 1.00 | – | – | 1.00 | – | – |
| Negative | 102 | 3.01 | 1.70-5.34 | .0002 | 1.16 | 0.52-2.58 | .71 |
| Grade | |||||||
| 1-2 | 142 | 1.00 | – | – | 1.00 | – | – |
| 3 | 107 | 2.14 | 1.18-3.88 | .013 | 0.80 | 0.39-1.63 | .54 |
| Intrinsic subtype | |||||||
| Luminal A | 111 | 1.00 | – | – | 1.00 | – | – |
| The others | 152 | 4.77 | 2.38-9.55 | <.0001 | 1.81 | 0.68-4.82 | .24 |
| TP53 signature | |||||||
| Wild-type signature | 166 | 1.00 | – | – | 1.00 | – | – |
| Mutant signature | 97 | 4.68 | 2.58-8.50 | <.0001 | 2.50 | 1.09-5.74 | .030 |
Abbreviations: CI, confidence interval; DRFS, distant recurrence-free survival; ER, estrogen receptor; HR, hazard ratio; PgR, progesterone receptor; RD, residual disease.