Table 2.
Association between symptoms of hyperandrogenemia and ovulatory dysfunction, social determinants of health, and comorbidities with the outcome of PCOS category, defined as self-reported PCOS, unrecognized PCOS, or no PCOS. Odds ratios and 95% confidence intervals (OR, 95% CI) shown. All models adjust for age, race (Black vs. White), and field center
| Self-reported PCOS, Reference = no PCOS OR (95% CI) |
Unrecognized PCOS, Reference = no PCOS OR (95% CI) |
||
|---|---|---|---|
| Model 1: Symptoms of hyperandrogenism and ovulatory dysfunction | |||
| Unwanted hair growth during 20-30 s | 4.58 (2.41, 8.7) | 17.22 (10.1, 29.35) | |
| Acne during 20-30 s | 0.85 (0.45, 1.59) | 1.3 (0.79, 2.15) | |
| Irregular menses during 20-30 s | 3.70 (1.85, 7.14) | * | |
| OCP use during 20 – 30 s | 0.63 (0.32, 1.24) | 0.24 (0.13, 0.44) | |
| Model 2: Social determinants of health | |||
| Food insecurity | 0.93 (0.37, 2.36) | 1.94 (1.25, 3.01) | |
| Did not seek care because of cost or lack of coverage | 0.97 (0.34, 2.75) | 1.2 (0.69, 2.10) | |
| Very hard, fairly hard, not too hard to get health services | 1.75 (0.86, 3.56) | 1.31 (0.86, 2.01) | |
| Model 3: Comorbidities | |||
| BMI category at year 15 | 1.83 (1.22, 2.75) | 1.04 (0.83, 1.3) | |
| Hypertension at year 15 | 0.75 (0.3, 1.91) | 1.68 (1.03, 2.74) | |
| Diabetes at year 15 | 2.37 (1.05, 5.33) | 1.26 (0.7, 2.29) | |
| Model 4: Symptoms, social determinants of health, and comorbidities | |||
| Unwanted hair growth during 20-30 s | 4.11 (2.13, 7.91) | 16.8 (9.72, 29.06) | |
| Acne during 20-30 s | 0.87 (0.46, 1.66) | 1.38 (0.82, 2.31) | |
| Irregular menses during 20-30 s | 3.70 (1.85, 7.69) | * | |
| OCP use during 20-30 s | 0.63 (0.32, 1.25) | 0.25 (0.13, 0.46) | |
| Food insecurity | 0.77 (0.32, 1.88) | 1.73 (0.87, 3.44) | |
| Did not seek care because of cost or lack of coverage | 1.14 (0.45, 2.93) | 1.38 (0.60, 3.17) | |
| Very hard, fairly hard, not too hard to get health services | 1.46 (0.71, 2.98) | 0.91 (0.49, 1.7) | |
| BMI category at year 15 | 1.71 (1.13, 2.59) | 1.17 (0.86, 1.60) | |
| Hypertension at year 15 | 0.76 (0.29, 1.94) | 1.60 (0.77, 3.33) | |
| Diabetes at year 15 | 2.18 (0.95, 5.04) | 0.86 (0.37, 1.96) | |
*By definition, the odds of having irregular menses are incorporated into the definition of unrecognized PCOS, and inclusion of this variable led to unstable model assumptions.