Table 3.
TumorScope Predict outcome metrics, overall and subgroups
| Overall (n = 80) | TNBC (n = 18) | HR−/HER2+ (n = 10) | HR+/HER2− (n = 28) | HR+/HER2+ (n = 24) | |
|---|---|---|---|---|---|
| AUROC (with volume threshold) | 0.910 | 0.938 | 0.917 | 0.75 | 0.919 |
| AUROC (with response threshold) | 0.905 | 0.900 | 0.812 | 0.823 | 0.944 |
| Accuracy | 0.912 (0.828, 0.964) | 0.944 (0.727, 0.999) | 0.900 (0.555, 0.998) | 0.893 (0.718, 0.977) | 0.917 (0.730, 0.989) |
| Sensitivity | 0.889 (0.708, 0.977) | 0.900 (0.555, 0.998) | 1.000 (0.398, 1.000) | 0.500 (0.068, 0.932) | 1.000 (0.664, 1.000) |
| Specificity | 0.925 (0.818, 0.979) | 1.000 (0.631, 1.000) | 0.833 (0.359, 0.996) | 0.958 (0.789, 0.999) | 0.867 (0.595, 0.983) |
| PPV | 0.857 (0.615, 0.958) | 1.000 (NA, NA) | 0.800 (0.309, 0.973) | 0.667 (0.018, 0.996) | 0.818 (0.460, 0.960) |
| NPV | 0.942 (0.883, 0.972) | 0.889 (0.500, 0.985) | 1.000 (NA, NA) | 0.920 (0.880, 0.947) | 1.000 (NA, NA) |
Accuracy represented as area under the receiver operating characteristic curve (AUROC) for the predicted pCR, computed either from a cutoff in the final volume or a cutoff in the response percentage (95% confidence intervals shown in parentheses; NA indicates confidence interval is undefined)