Table 3.
Diagnostic yield and sensitivity for malignancy
| Diagnostic Outcomes | N = 264 | |||
| % (95% CI) | ||||
| Diagnostic yield at index, using first definition | 85.2% (80.9%, 89.5%) | |||
| Diagnostic yield at 12 months, using first definition | ||||
| Base case | 79.4% (74.4%, 84.3%) | |||
| Worst case | 77.3% (72.2%, 82.3%) | |||
| Best case | 79.9% (75.1%, 84.8%) | |||
| Sensitivity for malignancy at 12 months | ||||
| Base case scenario | 79.3% (72.7%, 85.9%) | |||
| Worst case scenario | 74.2% (67.3%, 81.1%) | |||
| Comparison of Diagnostic Yield Definitions | ||||
| Index Diagnostic yield | 12-month Diagnostic yield | |||
| Index Diagnosis Status |
First Definition |
Second Definitiona |
First Definition |
Second Definition |
| Malignant | TP (N = 115) | TP (N = 115) | TP (N = 115) | TP (N = 115) |
| Benign specific | TN (N = 32) | TN (N = 40) | TN (N = 32) | TN (N = 32) |
| Benign non-specific | TN (N = 78) | FN (N = 70) |
TN (N = 57), FN (N = 14), or inconclusive (N = 7) |
TN (N = 57), FN (N = 14), or inconclusive (N = 7) |
| Non-diagnostic | FN (N = 39) | FN (N = 39) | FN (N = 39) |
TN (N = 22), FN (N = 14), or inconclusive (N = 3) |
| Diagnostic Yield | ||||
| Numerator | 225 | 155 | 204 | 226 |
| Denominator | 264 | 264 | 257 | 254 |
|
Estimate, % (95% CI) |
85.2% (80.9%, 89.5%) |
58.7% (52.8%, 64.7%) |
79.4% (74.4%, 84.3%) |
89.0% (85.1%, 92.8%) |
CI, confidence interval
aCases of organizing pneumonia and interstitial lung disease were classified as benign specific