Table 6.
Studies evaluating maternal BMI as a determinant of maternal or neonatal PFAS concentrations by PFAS, study design, and findings
PFAS (study design) a | N | Positive findings | N | Negative findings | N | Null findings |
---|---|---|---|---|---|---|
Legacy PFAS | ||||||
PFOA (C/L) | – | – | – | – | 8 | [42, 61, 62, 65, 78, 81, 82, 88] |
PFOA (C-S) | 1 | [89] | 2 | [91, 93] | 9 | [66, 67, 72, 74, 83, 86, 87, 92, 94] |
PFOS (C/L) | 2 | [78, 88] | 1 | [42] | 5 | [61, 62, 65, 81, 82] |
PFOS (C-S) | 1 | [89] | 4 | [67, 74, 83, 91] | 7 | [66, 72, 86, 87, 92–94] |
PFNA (C/L) | – | – | 3 | [42, 78, 82] | 2 | [65, 81] |
PFNA (C-S) | 1 | [86] | 1 | [94] | 7 | [66, 74, 83, 87, 89, 91, 93] |
PFHxS (C/L) | – | – | – | – | 8 | [42, 61, 62, 65, 78, 81, 82, 88] |
PFHxS (C-S) | 2 | [66, 89] | 2 | [74, 87] | 5 | [83, 86, 91, 93, 94] |
Other PFAS | ||||||
Et-PFOSA-AcOH (C/L) | 1 | [78] | – | – | – | – |
Me-PFOSA-AcOH (C/L) | 1 | [78] | – | – | 1 | [42] |
NMeFOSAA (C-S) | – | – | – | – | 1 | [74] |
PFDeA (C/L) | – | – | 2 | [65, 82] | – | – |
PFDeA (C-S) | 1 | [86] | 1 | [93] | 2 | [74, 87] |
PFDoA (C/L) | – | – | 1 | [82] | 1 | [88] |
PFDoA (C-S) | 1 | [86] | – | – | 1 | [87] |
PFHpA (C-S) | 1 | [86] | – | – | – | – |
PFHpS (C/L) | – | – | – | – | 1 | [65] |
PFHpS (C-S) | – | – | – | – | 1 | [93] |
PFOSA (C-S) | – | – | – | – | 1 | [86] |
PFPeA (C-S) | – | – | – | – | 1 | [74] |
PFTrDA (C/L) | – | – | 1 | [82] | – | – |
PFTrDA (C-S) | – | – | – | – | 1 | [87] |
PFUnDA (C/L) | – | – | 1 | [65] | 2 | [82, 88] |
PFUnDA (C-S) | – | – | 2 | [74, 93] | 3 | [86, 87, 89] |
6:2 Cl-PFESA (C/L) | – | – | 1 | [88] | – | – |
ΣPFAS (C-S) | – | – | – | – | 1 | [87] |
a C/L Cohort/longitudinal studies, C-S Cross-sectional studies, PFOA Perfluorooctanoic acid, PFOS Perfluorooctane sulfonic acid, PFNA Perfluorononanoic acid, PFHxS Perfluorohexane sulfonate, Et-PFOSA-AcOH 2-(N-Ethyl-perfluorooctane sulfonamido) acetic acid, Me-PFOSA-AcOH 2-(N-Methyl-perfluorooctane sulfonamido) acetic acid, NMeFOSAA N-methyl perfluorooctanesulfonamidoacetic acid, PFDeA Perfluorodecanoic acid, PFDoA Perfluorododecanoic acid, PFHpA Perfluoroheptanoic acid, PFHpS Perfluoroheptanesulfonic acid, PFOSA Perfluorooctanesulfonamide, PFPeA Perfluoropentanoic acid, PFTrDA Perfluorotridecanoic acid, PFUnDA Perfluoroundecanoic acid, 6:2 Cl-PFESA Chlorinated polyfluorinated ether sulfonate