Table 2.

HTR1A and TPH2 candidate SNPs and association with risk of LPE in allele model

SNP	Chr	Position	Gene(s)	Role	Alleles	Frequency (MAF)		p - HWE	OR (95% CI)	p value
						Cases	Controls
rs878567	5	63,960,164	HTR1A	ncRNA_intronic	G/A	0.181	0.184	0.034	0.98(0.65–1.50)	0.941
rs6294	5	63,961,426	HTR1A	exonic	T/C	0.181	0.184	0.034	0.98(0.65–1.50)	0.941
rs6295	5	63,962,738	HTR1A	ncRNA_intronic	G/C	0.203	0.193	0.011	1.07(0.71–1.61)	0.743
rs11178996	12	71,937,074	TPH2	intergenic	G/A	0.341	0.431	0.041	0.68(0.49–0.96)	0.027 *
rs11178997	12	71,938,373	TPH2	upstream	A/T	0.231	0.215	0.212	1.09(0.74–1.61)	0.655
rs11179001	12	71,944,865	TPH2	intronic	A/G	0.456	0.436	<0.001	1.08(0.78–1.50)	0.634
rs10879346	12	71,958,055	TPH2	intronic	T/C	0.407	0.429	0.335	0.91(0.65–1.27)	0.579
rs1386492	12	71,968,485	TPH2	intronic	T/C	0.434	0.367	0.572	1.32(0.95–1.84)	0.098
rs11179023	12	71,978,617	TPH2	intronic	A/G	0.17	0.200	0.324	0.82(0.53–1.26)	0.361
rs7305115	12	71,979,082	TPH2	exonic	A/G	0.44	0.384	0.657	1.26(0.91–1.75)	0.170
rs11179041	12	72,010,169	TPH2	intronic	A/G	0.198	0.802	0.216	0.89(0.60–1.34)	0.590
rs10879352	12	72,013,178	TPH2	intronic	C/T	0.198	0.802	0.218	0.88(0.59–1.32)	0.548
rs120074175	12	72,031,544	TPH2	exonic	A/G	0.192	0.808	0.210	0.90(0.59–1.35)	0.599

SNP: Single nucleotide polymorphism; HWE: Hardy-Weinberg equilibrium; ORs: Odds ratio; 95% CI: 95% confidence intervals;

^*p - HWE obtained from Fisher’s exact test