Table 4.

Relationship between candidate gene polymorphism and leptin, 5-HT, and folic acid levels in LPE patients

SNP	Model	Genotype	Leptin (ng/mL)	5-HT (ng/mL)	Folic acid
rs11178997	Co-dominant	TT(n = 29)	2.29 ± 2.21	40.06 ± 50.25	40.06 ± 50.25
		AT(n = 12)	0.75 ± 0.41	40.30 ± 43.24	40.30 ± 43.24
		AA(n = 7)	0.95 ± 0.82	35.61 ± 28.10	35.61 ± 28.10
		p-value	0.027 *	0.972	0.548
	Dominant	TT(n = 29)	2.29 ± 2.21	40.06 ± 50.25	52.91 ± 44.92
		AT-AA(n = 19)	0.83 ± 0.58	38.58 ± 37.57	59.16 ± 50.83
		p-value	0.007 *	0.913	0.657
	Recessive	TT-AT(n = 28)	0.95 ± 0.82	35.61 ± 28.10	73.50 ± 57.53
		AA(n = 7)	1.84 ± 1.99	40.13 ± 47.77	52.29 ± 44.98
		p-value	0.255	0.810	0.274
rs10879346	Co-dominant	TT(n = 16)	1.25 ± 1.29	54.26 ± 57.45	45.20 ± 40.79
		TC(n = 25)	1.97 ± 2.26	27.35 ± 27.16	52.40 ± 40.62
		CC(n = 7)	1.85 ± 1.52	48.96 ± 59.33	89.33 ± 69.47
		p-value	0.488	0.149	0.103
	Dominant	TT(n = 16)	1.25 ± 1.29	54.26 ± 57.45	45.20 ± 40.79
		TC-CC(n = 32)	1.94 ± 2.10	32.08 ± 36.53	60.47 ± 49.52
		p-value	0.232	0.110	0.293
	Recessive	TT-TC(n = 41)	1.85 ± 1.52	48.96 ± 59.33	89.33 ± 69.47
		CC(n = 7)	1.69 ± 1.96	37.85 ± 43.09	49.59 ± 40.33
		p-value	0.834	0.554	0.037 *
rs1386492	Co-dominant	CC(n = 17)	1.78 ± 2.20	35.40 ± 41.60	68.93 ± 56.25
		TC(n = 22)	1.79 ± 1.79	27.01 ± 29.24	51.42 ± 44.64
		TT(n = 9)	1.40 ± 1.64	77.63 ± 64.89	39.49 ± 25.63
		p-value	0.864	0.013 *	0.277
	Dominant	CC(n = 17)	1.78 ± 2.20	35.40 ± 41.60	68.93 ± 56.25
		T/C-TT(n = 31)	1.67 ± 1.73	41.71 ± 47.61	47.95 ± 40.00
		p-value	0.858	0.649	0.140
	Recessive	T/C-C/C(n = 39)	1.78 ± 1.95	30.67 ± 34.91	59.05 ± 50.11
		TT(n = 9)	1.40 ± 1.64	77.63 ± 64.89	39.49 ± 25.63
		p-value	0.587	0.004 *	0.264
rs11178996	Co-dominant	AA(n = 27)	1.96 ± 1.44	43.30 ± 57.21	83.64 ± 66.30
		AG(n = 13)	2.62 ± 2.89	33.86 ± 34.20	64.40 ± 49.40
		GG(n = 8)	1.20 ± 1.14	41.04 ± 47.47	42.67 ± 34.86
		p-value	0.073	0.87	0.065
	Dominant	AA(n = 27)	1.20 ± 1.14	41.04 ± 47.47	42.67 ± 34.86
		AG-GG(n = 21)	2.37 ± 2.42	37.46 ± 43.24	71.73 ± 55.63
		p-value	0.031 *	0.789	0.032 *
	Recessive	AA-AG(n = 40)	1.96 ± 1.44	43.30 ± 57.21	83.64 ± 66.30
		GG(n = 8)	1.66 ± 1.97	38.71 ± 43.29	49.73 ± 40.83
		p-value	0.687	0.796	0.061

SNP: Single nucleotide polymorphism; ORs: Odds ratio; 95% CI: 95% confidence intervals;

p-value calculated by logistic regression analysis with adjustments for gender and age;

^* Bold values indicate statistical significance (p < 0.05)