Table 2:

Characterization of Depression

Cerebral Folate Deficiency-Depressed Participants	*Number of Depressed Episodes	*Age at Onset of Depression (years)	*Level of Impairment: 1=Impaired, 2=Incapacitated	*Duration of Longest Episode (weeks)	*Number of Suicide Attempts	Comorbid Disorder	History of Bipolar Disorder yes/no	Family History of MDD yes/no	Family History of BP yes/no	Number of Medication Trials	ECT yes/no
1	2	15	2	600	1	PTSD and Anxiety	no	yes	yes	6	no
2	1	9	2	468	1	Anxiety	no	yes	no	>10	yes
3	2	12	2	468	5	PTSD, Anxiety, and ADHD	no	yes	no	8	no
4	1	26	2	208	4	PTSD	no	no	yes	4	yes
5	>100	9	2	50	0	PTSD, ADHD, and Substance Use Disorder	yes	yes	yes	9	no
6	2	16	2	312	0	Substance Use Disorder	no	yes	no	4	no
7	2	12	2	72	0	Anxiety	no	no	no	4	no
8	2	13	2	156	5	PTSD	no	yes	no	>10	no
9	1	20	2	28	1	none	no	no	no	3	no
10	1	4	2	1300	3	PTSD and Anxiety	no	yes	no	9	no
11	1	11	2	362	0	PTSD	no	yes	yes	3	yes
12	90	14	2	12	0	Substance Use Disorder	no	no	yes	3	no
Other Metabolic Disorders-Depressed Participants	* Number of Depressed Episodes	* Age at Onset of Depression (years)	* Level of Impairment: 1=Impaired, 2=Incapacitated	* Duration of Longest Episode (weeks)	* Number of Suicide Attempts	Comorbid Disorder	History of Bipolar Disorder yes/no	Family History of MDD yes/no	Family History of BP yes/no	Number of Medication Trials	ECT yes/no
13	1	5	2	1092	0	OCD and PTSD	no	yes	no	4	no
14	2	5	2	468	0	Anxiety	no	yes	no	5	no
15	1	12	2	1352	10	PTSD and Psychosis NOS	yes	yes	yes	>10	no
16	2	13	2	364	0	Anxiety	no	yes	no	6	yes
17	>100	21	2	104	1	Anxiety	yes	no	no	>10	no
18	1	17	2	1092	0	PTSD	yes	yes	yes	>10	no
19	1	13	2	364	1	Anxiety and ADHD	no	yes	no	9	no
20	2	11	2	208	0	Anxiety and OCD	no	no	no	4	no
21	15	8	2	12	2	Anxiety	no	yes	yes	10	no
No Metabolic Disorder-Depressed Participants	* Number of Depressed Episodes	* Age at Onset of Depression (years)	* Level of Impairment: 1=Impaired, 2=Incapacitated	* Duration of Longest Episode (weeks)	* Number of Suicide Attempts	Comorbid Disorder	History of Bipolar Disorder yes/no	Family History of MDD yes/no	Family History of BP yes/no	Number of Medication Trials	ECT yes/no
22	6	9	2	468	1	PTSD and Anxiety	no	yes	no	6	no
23	1	12	2	884	2	none	no	yes	yes	8	no
24	5	9	2	728	0	none	no	yes	no	7	no
25	1	23	2	572	0	Anxiety	no	no	no	10	no
26	2	6	2	364	0	none	no	yes	no	8	no
27	1	10	2	416	2	Anxiety	no	yes	no	6	no
28	1	13	2	364	4	PTSD and Psychosis	no	yes	no	>10	yes
29	1	14	1	1042	0	PTSD, Anxiety, and Substance Use Disorder	no	yes	yes	7	no
30	1	7	2	780	0	none	no	yes	no	4	no
31	4	13	2	36	1	Anxiety	no	yes	no	4	no
32	1	12	2	208	1	Anxiety	no	no	no	5	no
33	5	16	2	24	0	none	no	yes	no	>10	no

PTSD=Post Traumatic Stress Disorder, ADHD=Attention Deficit Hyperactivity Disorder, OCD= Obsessive Compulsive Disorder

^*Assessed from Family Interview for Genetic Studies (FIGS) reports.