Table 4:
Depressed Participants with a Metabolic Disorder and with No Metabolic Disorder: Findings
| Other Metabolic Disorders-Depressed Participants | Metabolic Findings | CSF 5-MTHF Levels nmol/L | Serum folate Levels ng/mL | Psychiatric Medications at Initial Visit | Initial SIQ | Initial BDI |
|---|---|---|---|---|---|---|
| 13 | Abnormal acylcarnitine profile | 68 | 17.6 | Citalopram, and Melatonin | 53 | 37 |
| 14 | Low creatine levels in urine/guan rat | 55 | 13.4 | Aripiprazole, Diazepam, Methylphenidate, Lamotrigine, and Bupropion | 15 | 38 |
| 15 | Abnormal acylcarnitine profile | 60 | >20.0 | Lamotrigine, Clonazepam, and Fluoxetine | 33 | 35 |
| 16 | Abnormal acylcarnitine profile | 109 | 19.3 | Levothyroxine Sodium, Lorazepam, Sertraline, Lurasidone, and Hydroxyzine | 36 | 29 |
| 17 | Fabry disease | 77 | 14.5 | Lithium Carbonate, and Desyrel | 15 | 19 |
| 18 | Abnormal acylcarnitine profile | 92 | 10.2 | Gabapentin, Lithium Carbonate, Lamotrigine, Clonazepam, and Olanzapine | 32 | 32 |
| 19 | Abnormal acylcarnitine profile and low creatine levels in urine/guan ratio | 59 | >20.0 | Nortriptyline and Sertraline | 72 | 32 |
| 20 | 20p12.1 microdeletion on chromosome analysis | 67 | >20.0 | Venlafaxine and Fluvoxamine | 22 | 24 |
| 21 | 15q13.3 microduplication on chromosome analysis | 45 | 16.6 | Desvenlafaxine, Divalproex Sodium, and Aripiprazole | 17 | 26 |
| No Metabolic Disorder-Depressed Participants | Other Findings | CSF 5-MTHF Levels nmol/L | Serum folate Levels ng/mL | Psychiatric Medications at Initial Visit | Initial SIQ | Initial BDI |
| 22 | 60 | 17.5 | Imipramine, Venlafaxine, and Quetiapine Fumarate | 37 | 41 | |
| 23 | 46 | >20.0 | Sertraline, and Quetiapine Fumarate | 59 | 33 | |
| 24 | 54 | >20.0 | Amitryptiline, Citalopram, Lovasal, and Levothyroxine Sodium | 12 | 12 | |
| 25 | 58 | 9.8 | Bupropion, Vilazodone, Temazepam, and Clonazepam | 11 | 19 | |
| 26 | 49 | 10.3 | Lamotrigine and Melatonin | 22 | 25 | |
| 27 | 52 | 17.6 | none | 41 | 22 | |
| 28 | 59 | >20.0 | Clozapine | 88 | 49 | |
| 29 | 53 | >20.0 | Venlafaxine | 11 | 17 | |
| 30 | 59 | 18.6 | Clonazepam | 55 | 39 | |
| 31 | 51 | >20.0 | none | 20 | 22 | |
| 32 | 78 | >20.0 | Fluoxetine, Lamotrigine, and Mirtazapine | 48 | 24 | |
| 33 | 48 | >20.0 | Lisdexamphetamine, Desyrel, and Levothyroxine Sodium | 49 | 30 |
CSF = Cerebrospinal Fluid, 5-MTHF = 5-Methyltetrahydrofolate, SIQ = Suicide Ideation Questionnaire, BDI = Beck Depression Inventory