Table 1.

Details of substitutions and anti-HIV activity for N-[4-(4’-chlorophenyl) thiazol-2-yl] thiosemicarbazide (3a–l, Fig. 7)

Compound No.	R	R1	EC50 (μg)a
3a	H	H	>12
3b	Cl	H	>10
3c	Br	H	>10
3d	H	-CH2-N(CH3)2	>54
3e	H		>57
3f	H		>19
3g	Cl	-CH2-N(CH3)2	>10
3h	Cl		>12
3i	Cl		>12
3j	Br	-CH2-N(CH3)2	>29
3k	Br		>21
3l	Br		>14

^aMT-4 cells are 50% protected by an effective concentration of the chemical from HIV’s cytotoxic effects