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. Author manuscript; available in PMC: 2023 May 10.
Published in final edited form as: Dev Biol. 2021 Feb 4;475:245–255. doi: 10.1016/j.ydbio.2021.01.018

Figure 1. Neural crest development and the genesis of metabolic neurocristopathies.

Figure 1.

(A) The neural crest is migratory stem cell population that delaminates from the dorsal neural tube and migrates extensively throughout the embryo. Neural crest development requires drastic changes in cellular metabolism for the proper migration and differentiation of these cells. (B) Environmental or genetic factors may disrupt the metabolic transitions observed in neural crest cells, resulting in congenital disorders known as metabolic neurocristopathies. FASD: Fetal alcohol spectrum disorder, ROS: Reactive oxygen species.