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. 2023 May 8;41(5):986–1002.e9. doi: 10.1016/j.ccell.2023.04.002

Figure 1.

Figure 1

A living biobank of MIND-PDX models of DCIS retaining histological and molecular features of primary lesions

(A) Schematic overview of the generation and characterization of 130 MIND-PDX models of DCIS.

(B) Pie chart of the grade distribution of the primary DCIS lesions.

(C) Pie chart of the DCIS take rate in MIND-PDX models.

(D) Examples of H&E-stained sections of the different growth patterns observed in primary DCIS lesions (top row) or DCIS-MIND outgrowths (middle row). Bottom row: human-specific Ku80 staining showing that DCIS-MIND outgrowths have a human origin.

(E) Distribution of growth patterns of primary DCIS lesions and the corresponding DCIS-MIND outgrowths. A black line indicates concordance between primary and PDX, whereas an orange line indicates a discordance between primary and PDX.

(F) Growth pattern analyses between an early (3–6 months) and late (12 months) time points.

(G) Examples of immunohistochemistry for ER, PR, HER2, and Ki67 expression in DCIS-MIND lesions (top row) vs. matched primary DCIS lesions (bottom row).

(H) Distribution of molecular subtypes (luminal A: ER+, PR+/−, HER2−, Ki67 < 20%; luminal B: ER+, PR+/−, HER2–, Ki67 ≥ 20%; HER2+: ER+/−, PR+/−, and HER2+; basal: ER−, PR−, HER2−) of primary DCIS lesions and the corresponding DCIS-MIND lesions. A black line indicates concordance between primary and PDX, whereas an orange line indicates a discordance between primary and PDX. See also Figure S1 and Table S1.