Figure 2.

DCIS-MIND models retain mutational and transcriptional features of the primary DCIS lesions

(A) Oncoprint showing the mutational landscape of the primary DCIS lesions, including amplifications, single-nucleotide variants, and insertion-deletions (indels) for the top mutated genes in our breast cancer gene panel. Annotations for each model includes ER, PR, and HER2 status.

(B) Oncoprint showing amplifications, single-nucleotide variants, and insertion-deletions (indels) in cancer genes in primary DCIS lesions and corresponding DCIS-MIND lesions for the top mutated genes.

(C) Unsupervised clustering of DCIS-MIND lesions based on PAM50 genes, showing clustering of luminal, HER2⁺, and basal-like DCIS lesions. Annotations include origin (primary or PDX) and molecular subtype based on PAM50 or IHC.

(D) Unsupervised clustering of DCIS-MIND lesions based on 90 informative genes resulting in three DCIS subtypes proposed by Strand et al.¹⁵ See also Figure S2 and Tables S2 and S3.