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Docking of cGMP to NKA in the high affinity ouabain conformation. Three principle docking positions of cGMP to the extracellular site of NKA are shown. cGMP is depicted as spheres with the highest scoring model in tan, followed by teal and orange colored models. Porcine NKA subunits α1, β1 and FXYD2 are shown as cartoon representations in tan, green and rose, respectively (PDB ID code 4HYT41).
