FIGURE 18.

Hematoxylin and eosin (H&E)‐stained cerebellum sections from rats treated with (a) normal saline (control) showing the normal layers architecture molecular layer (ML), Purkinje layer (PL), and granular layer (GL): normal piriform‐shaped Purkinje cells (black arrow). (b) 100 mg/kg of curcumin (Cur 100) showing vacuolar spaces and irregular Purkinje cells with eosinophilic cytoplasm (yellow arrow). (c) 50 mg/kg of Cur‐CSCaCO₃NP (Cur‐CSCaCO₃NP 50) shows fewer damaged Purkinje cells and very reduced vacuolar spaces around the cells. (d) 100 mg/kg of Cur‐CSCaCO₃NP (Cur‐CSCaCO₃NP 100) showing marked improved normal Purkinje cell morphology with prominent nuclei (green arrow). (H&E, ×20, scale bar = 100 μm)