FIGURE 19.

Toluidine blue‐stained cerebellum sections from rats treated with (a) normal saline (control) showing the normal layers architecture molecular layer (ML), Purkinje layer (PL), and granular layer (GL): And normal piriform‐shaped Purkinje cells (black arrow). (b) 100 mg/kg of curcumin (cur 100) showing vacuolar spaces and irregular Purkinje cells with eosinophilic cytoplasm (yellow arrow). (c) 50 mg/kg of cur‐CSCaCO₃NP (cur‐CSCaCO₃NP 50) showing fewer damaged Purkinje cells. (d) 100 mg/kg of cur‐CSCaCO₃NP (cur‐CSCaCO₃NP 100) showing marked improved layers organization and restoration of normal Purkinje cell morphology (green arrow). (e) Quantitative representation of degenerated Purkinje cells of the control and all the treated groups. *p < 0.05 versus control, n = 5. (Toluidine blue, ×20, scale bar = 100).