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. 2023 May 10;18(5):e0284733. doi: 10.1371/journal.pone.0284733

Table 6. Estimated number of deaths that could be averted or delayed if Canadians were to meet the sodium Adequate Intake (AI) recommendation of 1,500 mg/day (corresponding to 3.75 g of salt/d) (scenario C)–presented by cause of death (95% UI).

Cause of death (ICD-10 Code) 1 Total n (95% UI) 2 % Men n (95% UI) 2 % Women n (95% UI) 2 %
Cardiovascular diseases 5296 (2190, 8311) 100 3069 (1296, 4897) 100 2195 (911, 3486) 100
Ischaemic heart diseases (CHD) (I20-25) 2452 (1008, 3845) 46.3 1623 (687, 2587) 52.9 813 (340, 1291) 37.0
Cerebrovascular diseases (Stroke) (I60-69) 1127 (458, 1783) 21.3 582 (247, 933) 19.0 537(223, 858) 24.5
Heart failure (I50) 618 (252, 1005) 11.7 312 (128, 508) 10.2 300 (122, 492) 13.7
Aortic aneurysm (I71) 149 (59, 242) 2.8 96 (39, 160) 3.1 50 (21, 84) 2.3
Pulmonary embolism (I26) 31 (10, 64) 0.6 16 (5, 33) 0.5 15 (5, 31) 0.7
Rheumatic heart disease (I05-09) 27 (7, 55) 0.5 11 (3, 22) 0.4 16 (5, 33) 0.7
Hypertensive disease (I10-15) 893 (367, 1403) 16.9 425 (181, 672) 13.8 461 (191, 738) 21.0
Total deaths under age 75 1878 (773, 2945) 35.5 1361 (571, 2180) 44.3 506 (211, 800) 23.1
% of CVD deaths that could have been averted or delayed (reference year: 2019) 3 9.1% 10.0% 7.9%

1. WHO, International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [70].

2. 95% UI are based on 10,000 iterations of Monte Carlo analysis.

3. Deaths in Canada (2019) attributable to the CVDs under study = 58,476 (men 30,663; women 27,813)

Note: total deaths averted or delayed represent less than the sum of its components, given that double counting has been accounted for in PRIME during the modelling process. Reference AI values for sodium intake are directed to individuals and not to the population average, however, for this study we assumed recommendations at the population level.