Skip to main content
NCBI home page
Journal of Medical Genetics logoLink to Journal of Medical Genetics
. 1990 Jul;27(7):433–436. doi: 10.1136/jmg.27.7.433

No evidence for genetic linkage of Gilles de la Tourette syndrome on chromosomes 7 and 18.

P Heutink 1, B J van de Wetering 1, G J Breedveld 1, J Weber 1, L A Sandkuyl 1, E J Devor 1, A Heiberg 1, M F Niermeijer 1, B A Oostra 1
PMCID: PMC1017180  PMID: 2395161

Abstract

Gilles de la Tourette syndrome is a heritable neuropsychiatric disorder. In order to determine the chromosomal localisation of the locus involved, genetic linkage studies were initiated in six extended families. The Gilles de la Tourette gene has been tentatively assigned to chromosome 18q22.1. In our present study no evidence for genetic linkage on chromosome 18 and chromosome 7 was obtained. Data from the markers tested made it possible to exclude the whole of chromosome 18 and the chromosome 7q21.3-qter region as a site for the Gilles de la Tourette gene.

Full text

PDF
433

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baron M., Shapiro E., Shapiro A., Rainer J. D. Genetic analysis of Tourette syndrome suggesting major gene effect. Am J Hum Genet. 1981 Sep;33(5):767–775. [PMC free article] [PubMed] [Google Scholar]
  2. Comings D. E., Comings B. G., Devor E. J., Cloninger C. R. Detection of major gene for Gilles de la Tourette syndrome. Am J Hum Genet. 1984 May;36(3):586–600. [PMC free article] [PubMed] [Google Scholar]
  3. Detera-Wadleigh S. D., Anderson S., Spindel E. R. A frequent Pvu II RFLP of the human gastrin releasing peptide gene. Nucleic Acids Res. 1987 Jan 12;15(1):375–375. doi: 10.1093/nar/15.1.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Devor E. J. Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission. Am J Hum Genet. 1984 May;36(3):704–709. [PMC free article] [PubMed] [Google Scholar]
  5. Devor E. J., Grandy D. K., Civelli O., Litt M., Burgess A. K., Isenberg K. E., van de Wetering B. J., Oostra B. Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22-q23 in Tourette syndrome. Hum Hered. 1990;40(2):105–108. doi: 10.1159/000153914. [DOI] [PubMed] [Google Scholar]
  6. Donnai D. Gene location in Tourette syndrome. Lancet. 1987 Mar 14;1(8533):627–627. doi: 10.1016/s0140-6736(87)90263-7. [DOI] [PubMed] [Google Scholar]
  7. Estivill X., Farrall M., Scambler P. J., Bell G. M., Hawley K. M., Lench N. J., Bates G. P., Kruyer H. C., Frederick P. A., Stanier P. A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands. 1987 Apr 30-May 6Nature. 326(6116):840–845. doi: 10.1038/326840a0. [DOI] [PubMed] [Google Scholar]
  8. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem. 1983 Jul 1;132(1):6–13. doi: 10.1016/0003-2697(83)90418-9. [DOI] [PubMed] [Google Scholar]
  9. Lathrop G. M., Lalouel J. M. Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet. 1984 Mar;36(2):460–465. [PMC free article] [PubMed] [Google Scholar]
  10. Lathrop G. M., Lalouel J. M., Julier C., Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443–3446. doi: 10.1073/pnas.81.11.3443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Marlhens F., Delattre O., Bernard A., Olschwang S., Dutrillaux B., Thomas G. RFLP identified by the anonymous DNA segment OL VII E10 at 18q21.3 (HGM no. D18S8). Nucleic Acids Res. 1987 Feb 11;15(3):1348–1348. doi: 10.1093/nar/15.3.1348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. O'Connell P., Lathrop G. M., Leppert M., Nakamura Y., Müller U., Lalouel J. M., White R. Twelve loci form a continuous linkage map for human chromosome 18. Genomics. 1988 Nov;3(4):367–372. doi: 10.1016/0888-7543(88)90129-2. [DOI] [PubMed] [Google Scholar]
  13. Pauls D. L., Leckman J. F. The inheritance of Gilles de la Tourette's syndrome and associated behaviors. Evidence for autosomal dominant transmission. N Engl J Med. 1986 Oct 16;315(16):993–997. doi: 10.1056/NEJM198610163151604. [DOI] [PubMed] [Google Scholar]
  14. Rommens J. M., Zengerling S., Burns J., Melmer G., Kerem B. S., Plavsic N., Zsiga M., Kennedy D., Markiewicz D., Rozmahel R. Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene. Am J Hum Genet. 1988 Nov;43(5):645–663. [PMC free article] [PubMed] [Google Scholar]
  15. Shaw D., Eiberg H. Report of the committee for chromosomes 17, 18, and 19. Cytogenet Cell Genet. 1987;46(1-4):242–256. doi: 10.1159/000132479. [DOI] [PubMed] [Google Scholar]
  16. Spindel E. R., Chin W. W., Price J., Rees L. H., Besser G. M., Habener J. F. Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5699–5703. doi: 10.1073/pnas.81.18.5699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tsui L. C., Farrall M., Donis-Keller H. Report of the committee on the genetic constitution of chromosomes 7 and 8. Cytogenet Cell Genet. 1989;51(1-4):166–201. doi: 10.1159/000132791. [DOI] [PubMed] [Google Scholar]
  18. Zavodny P. J., Petro M. E., Kumar C. C., Dailey S. H., Lonial H. K., Narula S. K., Leibowitz P. J. The nucleotide sequence of chicken smooth muscle myosin light chain two. Nucleic Acids Res. 1988 Feb 11;16(3):1214–1214. doi: 10.1093/nar/16.3.1214. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Publishing Group

RESOURCES