FIG. 4.

Postoperative management algorithm after NIFTP diagnosis. Tumors are divided into Groups 1–3: Group 1 being NIFTP-only, Group 2 is NIFTP plus a single PTMC, and Group 3 is NIFTP plus additional malignancies (multiple microcarcinomas, PTC >1.0 cm, non-PTCs). Group 1 patients and patients in Group 2 with incidentally detected single foci of PTMC should be followed routinely, as any patient diagnosed with a benign thyroid tumor would be followed. Patients in Group 2 with nonincidental PTMC should be followed with active surveillance. Patients in Group 3 should be followed based on their concomitant disease process, indifferent to NIFTP, some with active surveillance and some with additional treatment.