Table 3.
Clinicopathological Characteristics of 183 Patients with Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features-only (Group 1)
| Clinicopathological characteristics | |
|---|---|
| Variables | Group 1 (n = 183) NIFTP-only, n/N (%) |
| Age, median | |
| Range (years) | 53 (19–87) |
| Sex | |
| Female | 135/183 (74) |
| Male | 48/183 (26) |
| Size of NIFTP, median | |
| Range (cm) | 2.3 (0.3–7.5) |
| ≤1.0 | 21/183 (12) |
| 1.1–2.0 | 55/183 (30) |
| 2.1–4.0 | 79/183 (43) |
| >4.0 | 28/183 (15) |
| Number of NIFTP | |
| 1 | 171/183 |
| 2 | 9/183 |
| 3 or more | 3/183 |
| NIFTP FNA | |
| Yes | 163/183 (89) |
| No | 20/183 |
| Bethesda system category of NIFTP, n = 163 | |
| Nondiagnostic | 6/163 (4) |
| Benign | 20/163 (12) |
| AUS/FLUS | 83/163 (51) |
| FN/SFN | 31/163 (19) |
| Suspicious for malignancy | 18/163 (11) |
| Malignant | 5/163 (3) |
| Molecular alterations in NIFTP, n = 79 | |
| Yes | 73/79 (92) |
| No | 6/79 |
| Gene identified | |
| Yes | 46/73 |
| Gene | |
| NRAS | 24/46 (52) |
| KRAS | 7/46 (15) |
| HRAS | 7/46 (15) |
| TAHDA fusion | 8/46 (17) |
| Suspicious Afirma | 26/73 (36) |
| BRAFVE IHC; n = 108 | |
| Positive | 0/108 |
| Negative | 106/108 (98) |
| Indeterminate | 2/108 (2) |
| HBME1 IHC; n = 93 | |
| Positive | 84/93 (90) |
| Negative | 9/93 |
| TI-RADS for NIFTP; n = 148 | |
| 1 | 2/148 (1) |
| 2 | 5/148 (3) |
| 3 | 38/148 (26) |
| 4 | 73/148 (50) |
| 5 | 30/148 (20) |
| Preoperative features | |
| Compression | 30/181 (17) |
| Thyroid function; n = 181 | |
| Euthyroid | 164/181 (91) |
| Hyperthyroid | 10/181 (6) |
| Hypothyroid | 7/181 (4) |
| Thyroid medication use | |
| Methimazole or thyroxine | 9/181 (5) |
| Non-NIFTP FNA | |
| Yes | 28/183 (15) |
| Bethesda system category for non-NIFTP FNA; n = 28 | |
| Nondiagnostic | 2/28 (7) |
| Benign | 15/28 (53) |
| AUS/FLUS | 8/28 (29) |
| FN/SFN | 1/28 (4) |
| Suspicious for malignancy | 2/28 (7) |
| Malignant | 0/28 (0) |
| Procedure | |
| Lobectomy/hemithyroidectomy | 120/183 (66) |
| Total thyroidectomy | 63/183 (34) |
| Completion thyroidectomy | |
| Yes | 0/118 (0) |
| No | 118/118 |
| NA | 2/120 |
| Lymph nodes sampling | |
| Yes | 64/183 |
| Positive lymph nodes | |
| Yes | 0/64 (0) |
| No | 64/64 |
| Radioactive iodine | |
| Yes | 0/152 (0) |
| No | 152/152 |
| Unknown (follow up <4 weeks) | 31/183 |
| Recurrence | |
| Yes | 0/128 (0) |
| No | 128/152 |
| Unknown (follow up <6 months) | 54/183 |
TI-RADS, Thyroid Imaging Reporting and Data System.