Table 4.
Clinicopathological and Radiological Characteristics for Patients with Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Feature-only (Group 1) and Correlation with Total Thyroidectomy on Univariate Analysis
| Clinicopathological and radiological characteristics | Hemithyroidectomy, N (%) or median (IQR); n = 120 | Total thyroidectomy, N (%) or median (IQR); n = 63 | p |
|---|---|---|---|
| Age (years) | 52 (39–65) | 56 (43–65) | 0.13 |
| Female | 87 (73) | 48 (76) | 0.59 |
| Bethesda system category of NIFTP | |||
| Nondiagnostic | 3 (3) | 3 (5) | 0.41 |
| Benign | 16 (13) | 4 (6) | 0.15 |
| AUS/FLUS | 59 (49) | 24 (38) | 0.15 |
| FN/SFN | 23 (19) | 8 (12) | 0.27 |
| Suspicious for malignancy | 8 (7) | 10 (16) | 0.05 |
| Malignant | 1 (1) | 4 (6) | 0.03 |
| Not performed | 10 (8) | 10 (15) | 0.11 |
| Underwent FNA of non-NIFTP nodule | 11 (9.2) | 17 (27) | 0.0015 |
| TI-RADS for NIFTP | |||
| 1 | 1 (1) | 1 (2) | 0.64 |
| 2 | 4 (3) | 1 (2) | 0.49 |
| 3 | 26 (22) | 12 (19) | 0.68 |
| 4 | 50 (42) | 23 (37) | 0.50 |
| 5 | 17 (14) | 13 (21) | 0.27 |
| TSH (mIU/mL) | 1.4 (1.0–2.3) | 1.6 (1.1–2.3) | 0.35 |
| Preoperative features | |||
| Compression | 16 (13.3) | 14 (22.2) | 0.12 |
| Euthyroid | 113 (94.2) | 51 (81.0) | 0.005 |
| Hyperthyroid | 3 (2.5) | 7 (11.1) | 0.02 |
| Hypothyroid | 2 (1.7) | 5 (7.9) | 0.04 |
| Thyroid medication use (methimazole and thyroxine) | 3 (2.5) | 6 (9.5) | 0.04 |
| Molecular testing | |||
| Suspicious | 45 (37.5) | 24 (38.1) | 0.94 |
| RAS (KRAS, NRAS, and HRAS) | 24 (20.0) | 14 (22.2) | 0.73 |
Bold: statistically significant.
IQR, interquartile range; TSH, thyrotropin.