Table 2. Clinical features of studies with re-irradiation in diffuse intrinsic pontine glioma.
| Study | Year | No of. patients | reRT dose (Gy) | reRT fractions | Median time from upfront RT to reRT (mo) | Concurrent CTx at reRT | Median OS from diagnosis (mo) | Median OS from reRT (mo) | Radiation necrosis (n) |
|---|---|---|---|---|---|---|---|---|---|
| Krishnatry and Manjali [46] | 2021 | 20 | 33.8–43.2 | 19–24 | 8.9 | N | 16.6 | 5.5 | - |
| Zaroma et al. [54] | 2021 | 5 | 20–24 | 10–12 | 10 | Y | 16.3 | 3.9 | 0 |
| Amsbaugh et al. [45] | 2019 | 12 | 24–30.8 | 10–12 | 12.3 | N | 19.5 | 5.8 | - |
| Kline et al. [42] | 2018 | 12 | 24 | 10–12 | 11.8 | Y | 20.8 | 6.8 | - |
| Lassaletta et al. [43] | 2018 | 16 | 21.6–36 | 10–17 | 13 | Y | 19.3 | 6.5 | 2 |
| Freese et al. [41] | 2017 | 3 | 20 | 10 | 14 | N | 17.3 | 2 | - |
| Janssens et al. [39] | 2017 | 31 | 18–30 | 10–11 | - | Y | 13.7 | - | 0 |
| Massimino et al. [44] | 2014 | 11 | 19.8 | 11 | - | Y | 16 | 6 | - |
| Fontanilla et al. [40] | 2012 | 5 | 18–20 | 10 | 12.5 | Y | - | 6 | 0 |
reRT, re-radiotherapy; RT, radiotherapy; CTx, chemotherapy; OS, overall survival