TABLE 3.

Detrimental effects of neprilysin (NEP) inhibitors.

Study type	Findings	Ref.
Experimental study	NEP inhibitors deteriorate glucose homeostasis and insulin sensitivity.	Becker et al 45
Experimental study	NEP‐deficient mice are susceptible to the development of obesity and impairment of glucose tolerance.	Poorgolizadeh et al 69
Experimental study	NEP inhibitors did not improve glycemic indices in rats.	Simonsen et al 39
Experimental study	NEP inhibitors did not improve glucose homeostasis and insulin sensitivity in rats with T2DM.	Davidson et al 70
A prospective study	Administration of ARNIs lead to hyperglycemia in T2DM patients.	Albrechtsen et al 15
A prospective, crossover study	ARNIs worsen postprandial glucose control in T2DM patients.	Wewer et al 71

Abbreviations: ARNI, angiotensin receptor/neprilysin inhibitor; NEP, neprilysin; T2DM. type 2 diabetes mellitus.