Table 3. Comparison of BNP and NT-proBNP.

Characteristic	BNP	NT-proBNP
Diagnosis of HF in non-acute setting	≥35 pg/mL	≥125 pg/mL
Diagnosis of HF in acute setting	≥100 pg/mL	≥300 pg/mL
Half-life	Shorter, more rapid changes in response to treatment	Longer, a more stable measurement over time
Response to neprilysin	Degradable	Non-degradable
Specificity	More specific, less influenced by age and renal function	Less specific, influenced by age and renal function

BNP = B-type natriuretic peptide; NT-proBNP = N-terminal-pro hormone B-type natriuretic peptide; HF = heart failure.