Table 7. Score-based diagnostic algorithm for heart failure with preserved ejection fraction: HFA-PEFF score93).
| Criteria | Functional | Structural | Biomarker (sinus rhythm) | Biomarker (atrial fibrillation) |
|---|---|---|---|---|
| Major | Septal e′ <7 cm/s or lateral e′ <10 cm/s or average E/e′ ≥15 or TR velocity ≥2.8 m/s (PASP >35 mmHg) | LAVI >34 mL/m2 or LVMI >149/122 g/m2 (male/female) and RWT >0.42 | NT-proBNP >220 pg/mL or BNP >80 pg/mL | NT-proBNP >660 pg/mL or BNP >240 pg/mL |
| Minor | Average E/e′ 9–14 or GLS <16% | LAVI 29–34 mL/m2 or LVMI >115/95 g/m2 (male/female) or RWT >0.42 or LV wall thickness ≥12 mm | NT-proBNP 125–220 pg/mL or BNP 35–80 pg/mL | NT-proBNP 365–660 pg/mL or BNP 105–240 pg/mL |
| Major criteria: 2 points | ≥5 points: HFpEF | |||
| Minor criteria: 1 point | 2–4 points: diastolic stress test or invasive hemodynamic assessment | |||
TR = tricuspid regurgitation; PASP = pulmonary arterial systolic pressure; LAVI = left atrial volume index; LVMI = left ventricular mass index; RWT = relative wall thickness; NT-proBNP = N-terminal pro b-type natriuretic peptide; BNP = brain natriuretic peptide; GLS = global longitudinal strain; LV = left ventricle; HFpEF = heart failure with preserved ejection fraction.