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. 2023 May 10;617(7960):335–343. doi: 10.1038/s41586-023-05976-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, PHRs are found on the rDNA-proximal regions of the SAACs chr. 13, chr. 14, chr. 15, chr. 21 and chr. 22. b, PHRs physically co-locate owing to their proximity to the nucleolar organizing regions and rDNA, encouraging sequence exchange. b, Patterns of sequence similarity observed in the PHRs indicate ongoing recombination exchange between heterologous chromosomes, in particular chr. 13, chr. 14 and chr. 21, which may be mediated by both non-crossover recombination or crossover of the telomeric ends of heterologous chromosomes. d, The PHR surrounding the SST1 arrays on chr. 13, chr. 14 and chr. 21 is nearly identical on all three chromosomes, but is typically inverted on chr. 14 relative to chr. 13 and chr. 21 (triangles). Owing to the inversion, crossover type recombination between PHRs in chr. 14 and chr. 13 or chr. 21 produce an ROB.