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. 2023 Apr 19;617(7960):351–359. doi: 10.1038/s41586-023-05964-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — In each individual participant, measures derived from each of the foot, hand, mouth, and inter-effector motor regions. Colored lines connect the same participant’s inter-effector and effector-specific regions for ease of comparison. a, Functional connectivity strength Z(r) between M1 region and individual-specific Cingulo-Opercular Network (CON). b, Functional connectivity between M1 region and middle insula. c, Functional connectivity with Lobule VIIIa vermis of the cerebellum. d, Functional connectivity between M1 region and dorsal posterior putamen. e—g, Functional connectivity between M1 region and nuclei of the thalamus: e, Centromedian nucleus; f, Ventral Intermediate nucleus; g, Ventral Posteromedial nucleus. h, Functional connectivity between M1 region and adjacent postcentral gyrus (S1). i, Cortical thickness in M1 region. j, Fractional Anisotropy within 2 mm below cortex under M1 region. k, Intracortical myelin, indexed by the T1/T2 ratio and normalized across cortex, within cortex of M1 region. All significance values reflect significance across three two-sided paired t-tests (inter-effector vs foot, vs hand, and vs mouth). * P < 0.05; ** P < 0.01; *** P < 0.001, FDR-corrected.