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. 2023 May 10;14:2692. doi: 10.1038/s41467-023-38360-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a H&E stain image of gastric cancer tissue section from patient “No.0429”, “No.0602”, and “No.0716”, scale bar = 2 mm. The experiment was repeated three times. b Fatty acid de novo synthesis pathway. c Synthesis and metabolism pathways of phosphatidylcholine and phosphatidylethanolamine. d MS images of representative lipids in gastric cancer tissues (intensity in colour scale is relative value). e Expression levels of representative lipids in different region spots of gastric cancer tissue from patient “No.0429” (seven tissue samples for spatial lipidomics, n = 6 independent section regions from patient “No.0429”, mean ± SD), p-values were calculated using the unpaired two-tailed t-test at confidence intervals 0.95. f Spatial expression images of key genes in lipid synthesis and metabolism pathways (intensity in colour scale is log2 transformed). g Expression levels of lipid metabolism-related key genes in different micro-regions of gastric cancer tissue from patient “No.0429”. TT Tumor tissue, TG Tumor and gland tissue, NE Normal epithelium, IM Intestinal metaplasia, LT Lymphoid tissue, MM Muscularis mucosa, PM Peritumoral muscularis, LM Lamina propria, CNT Connective tissue, SGS Serrated glandular structure, HCM Heterotopic cystic malformation.